363605
IK (IK Cytokine, Down Regulator Of HLA II, RED, RER, IK factor)
Size
£544.00
- SKU:
- 363605
- Purity:
- Purified by Protein A and peptide affinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to Met1-Pro192 of human IK, expressed in E. coli.
- Format:
- Supplied as a liquid in 0.01M PBS, pH7.4, 0.05% Proclin-300, 50% glycerol.
- Extra Details:
- IK is in fact part of a larger gene encoding a 557aa protein that is 98% identical to the mouse sequence and contains an extensive stretch of arg-glu-asp (RED) repeats. Notably, the codon usage in the RED repeat is varied, suggesting the sequence is not a result of repetitive duplication. RE repeats are found in atrophin-1, and RD repeats are found in RD. RED is expressed in both bacterial and mammalian cells as an 80kD protein. Sequence analysis predicted and immunofluorescence analysis demonstrated that RED is localized to nuclear dots similar to the expression pattern of PML bodies; however, RED does not colocalize with PML or coilin (COIL) and appears to be sequestered from the nucleoplasm. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice