363580
IgA1 (Immunoglobulin A1, IGHA1, Immunoglobulin heavy constant alpha 1, Ig alpha-1 chain C region)
Size
£626.00
- SKU:
- 363580
- Purity:
- Purified by Protein A and peptide affinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Native protein corresponding to human IgA1.
- Format:
- Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
- Extra Details:
- IgA1 protein isolated from patients with IgA nephropathy (IGAN1) were galactosylated to a lesser degree compared to controls. The galactose deficiency was in the O-linked side chains located in the hinge region of the IgA1 molecule. Incompletely galactosylated IgA1 was detected in complexes with IgG, supporting the hypothesis that the formation of abnormal IgA1-IgG complexes impairs the rate of elimination and hepatic catabolism of IgA1 in patients with IgA nephropathy. The signal peptide and first 2 extracellular residues of IRTA1 are fused to the extracellular spacer, transmembrane domain, and cytoplasmic tail of the membrane IgA1 receptor (IGHA1) in the FR4 multiple myeloma (MM) cell line, but not in other MM or lymphoma cell lines. They concluded that the IRTA1-IGHA1 fusion may be a rare event in B-cell malignancy. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice