HSD17b10 (17-Beta-Hydroxysteroid Dehydrogenase Type 10, 17b-HSD10, ABAD, ERAB, HADH2, HCD2, MHBD, SCHAD, SDR5C1, MRPP2, CAMR, 3-Hydroxyacyl-CoA Dehydrogenase Type-2, AB-Binding Alcohol Dehydrogenase)

Size

£537.00

SKU:: 363510
Purity:: Purified by Protein A and peptide affinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Recombinant protein corresponding to Ala4-Ala202 of mouse HSD17b10, expressed in E. coli.
Format:: Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Extra Details:: HSD17b10 has been implicated in the development of Alzheimer's disease, and mutations in the gene are the cause of 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency (MHBD). ERAB was expressed in normal tissues but was overexpressed in neurons from patients with Alzheimer disease. ERAB immunoprecipitated with beta-amyloid, and when cell cultures were exposed to beta-amyloid, ERAB inside the cell was rapidly redistributed to the plasma membrane. SCHAD is a multifunctional enzyme. Immunohistochemical analysis showed that mature SCHAD localized to the mitochondria. SCHAD is a single-domain multifunctional enzyme that functions in 2 different pathways of lipid metabolism: mitochondrial fatty acid oxidation and steroid hormone metabolism. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice