363447
HEXa (Hexosaminidase A Alpha, TSD, Hex-A, Tay Sachs Disease, GM2 Gangliosidosis, Beta-Hexosaminidase Subunit Alpha, Beta-N-Acetylhexosaminidase Subunit Alpha, N-Acetyl-Beta-Glucosaminidase Alpha)
Size
£482.00
- SKU:
- 363447
- Application:
- WB
- Purity:
- Purified by Protein A and peptide affinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to His318-Thr529 of human HEXa, expressed in E. coli.
- Format:
- Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
- Extra Details:
- Hexosaminidase A (alpha polypeptide),is an enzyme that is encoded by the HEXA gene. Beta-hexosaminidase occurs as two major isozymes: hexosaminidase A and hexosaminidase B. Hexosaminidase A and the cofactor GM2 activator protein catalyze the degradation of the GM2 gangliosides and other molecules containing terminal N-acetyl hexosamines.Hexosaminidase A is a heterodimer composed of an alpha and beta subunit. The alpha subunit is encoded by the HEXA gene while the beta subunit is encoded by the HEXB gene. Gene mutations in the gene encoding the beta subunit (HEXB) often result in Sandhoff disease; whereas, mutations in the gene encoding the alpha subunit (HEXA, this gene) decrease the hydrolysis of GM2 gangliosides, which is the main cause of Tay-Sachs disease. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice