363365
GRK4 (G Protein Coupled Receptor Kinase 4, GPRK2L, GPRK4, GRK4a, IT11, G protein-coupled receptor kinase GRK4)
Size
£626.00
- SKU:
- 363365
- Purity:
- Purified by Protein A and peptide affinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to Phe187-Phe449 of human GRK4, expressed in E. coli.
- Format:
- Supplied as a liquid in 0.01M PBS, pH7.4, 0.05% Proclin-300, 50% glycerol.
- Extra Details:
- G protein-coupled receptor kinase 4 is a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. G protein-coupled receptor kinases are a family of serine/threonine kinases that appear to play a role in receptor desensitization. Beta-adrenergic receptor kinase-1 and rhodopsin kinase are examples. They phosphorylate the activated form of the corresponding receptor, increasing its ability to interact with beta-arrestin or retinal arrestin, respectively. Binding of the arrestins to the receptors then blocks further activation of the respective signal transduction pathways. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice