363303
GLMN (Glomulin, FAP, FAP48, FAP68, FKBPAP, GLML, GVM, VMGLOM, FK506-binding protein-associated protein, FKBP Associated Protein, Venous Malformation With Glomus Cells)
Size
£537.00
- SKU:
- 363303
- Purity:
- Purified by Protein A and peptide affinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to Val294-Pro549 of mouse GLMN, expressed in E. coli.
- Format:
- Supplied as a liquid in 0.01M PBS, pH7.4, 0.05% Proclin-300, 50% glycerol.
- Extra Details:
- Glomulin is essential for normal development of the vasculature and mutations in this gene have been associated with glomuvenous malformations, also called glomangiomas. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined. The cDNA sequence encodes a protein of 417aa. This novel protein, named FAP48 for FKBP-associated protein, can interact with FKBP59 and FKBP12 both in vitro and in vivo; however, binding is inhibited by FK506 and rapamycin in a dose-dependent manner. FAP48 may therefore represent a naturally occurring ligand of these immunosuppressant drug receptors. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice