363235
GBP4 (Guanylate Binding Protein 4, GTP-binding protein 4, Guanine nucleotide-binding protein 4)
Size
£495.00
- SKU:
- 363235
- Purity:
- Purified by Protein A and peptide affinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to Met1-Cys304 of mouse GBP4, expressed in E. coli.
- Format:
- Supplied as a liquid in 0.01M PBS, pH7.4, 0.05% Proclin-300, 50% glycerol.
- Extra Details:
- Guanylate-binding proteins, such as GBP4, are induced by interferon and hydrolyze GTP to both GDP and GMP.Vestal (2005) reported that the 642aa GBP4 protein shares 50 to 55% identity with GBP1 , GBP2 , and GBP5 . GBP4 contains a GTP-binding domain, but it lacks a C-terminal CaaX isoprenylation motif found in the other 3 GBPs. Olszewski et al. (2006) found that GBP4 shares 74% and 81% aa identity with GBP6 and GBP7 , respectively. All GBPs, including GBP4, have a conserved N-terminal globular GTP-binding domain containing 2 consensus sequences and a third T(L/V)RD sequence not found in other GTPases. GBP4 has a unique 15aa group at its N terminus that is not found in other GBPs. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice