GAL2 (Galectin 2, LGALS2, HL14, Lectin,Galactoside-Binding Soluble 2, Beta-galactoside-binding lectin L-14-II, Lactose-binding lectin 2, S-Lac lectin 2)

Size

£513.00

SKU:: 363203
Purity:: Purified by Protein A and peptide affinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Recombinant protein corresponding to Met1-Phe123 of porcine GAL2, expressed in E. coli.
Format:: Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Extra Details:: The galectins constitute a large family of carbohydrate-binding proteins that function in many systems both intracellularly and following secretion.Galectins contain either one or two carbohydrate recognition domains (CRR) which mediate recognition of N-acetyl-lactosamine-containing glycoproteins. Galectin-2, a lectin binding to beta-galactoside, was found to trigger apoptosis of activated T cells and leaves naive or memory T cells unaltered. Cytokine secretion of activated T cells was significantly shifted to the Th2 profile. In vivo experiments showed a significant decrease of bowel inflammation during the course of several days in galectin-2 treated mice featuring DSS-colitis. Furthermore, contact hypersensitivity (CHS) responses were reduced significantly in Galectin-2 treated mice after sensitization to contact allergens. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice