363159
FRS2 (Fibroblast Growth Factor Receptor Substrate 2, FLRG, FSRP, Follistatin-Related Protein,Secreted Glycoprotein, Follistatin-related gene protein)
Size
£537.00
- SKU:
- 363159
- Application:
- WB
- Purity:
- Purified by Protein A and peptide affinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to Leu268-Pro453 of mouse FRS2, expressed in E. coli.
- Format:
- Supplied as a liquid in 0.01M PBS, pH 7.4, 0.05% Proclin-300, 50% glycerol.
- Extra Details:
- The deduced 508aa protein has a predicted molecular mass of 56.8kD. It contains a myristylation sequence, a phosphotyrosine-binding (PTB) domain, and 4 potential GRB2-binding sites. Northern blot analysis of adult mouse tissues detected ubiquitous expression of Frs2, with highest levels in brain, kidney, lung, ovary, and testis. SDS-PAGE showed that FRS2 migrates as doublet of 92 to 95 kD. Melillo et al. (2001) presented evidence that FRS2 couples both ligand-regulated and oncogenic forms of RET with the MAPK signaling cascade under normal biologic conditions and pathologic conditions, such as multiple endocrine neoplasias and papillary thyroid carcinomas. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap
- Shipping Conditions:
- Blue Ice