362829
DEFb1 (Defensin Beta 1, B-DF1, DEFB1, BD1, DEF-B1, DEFB101, HBD1)
Size
£524.00
- SKU:
- 362829
- Application:
- WB
- Purity:
- Purified by Protein A and peptide affinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to Arg2-Arg64 of bovine DEFb1, expressed in E. coli.
- Format:
- Supplied as a liquid in 0.01M PBS, pH 7.4, 0.05% Proclin-300, 50% glycerol.
- Extra Details:
- The underlying genes responsible for defensin production are highly polymorphic. Some aspects are conserved, however; the hallmarks of a beta-defensin are its small size, high density of cationic charge and six-cysteine-residue motif. Generally they are encoded by two-exon genes, where the first exon encodes for a hydrophobic leader sequence and the second for a peptide containing the cysteine motif. There are three main (known) forms of mammalian defensins; alpha-defensins, beta-defensins, and theta-defensins. It is theorised that some of the pathology of cystic fibrosis arises from the inhibition of beta-defensin activity on the epithelial surfaces of the lungs and trachea due to higher salt content. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice