CLEC11A (C-Type Lectin Domain Family 11, Member A, SCGF, P47, LSLCL, CLECSF3, Stem Cell Growth Factor, Lymphocyte Secreted C-Type Lectin, C-type lectin superfamily member 3)

Size

£517.00

SKU:: 362591
Application:: WB
Purity:: Purified by Protein A and peptide affinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Recombinant protein corresponding to Ala22-Phe323 of human CLEC11A, expressed in E. coli.
Format:: Supplied as a liquid in 0.01M PBS, pH 7.4, 0.05% Proclin-300, 50% glycerol.
Extra Details:: CLEC11A encodes a member of the C-type lectin superfamily. The encoded protein is a secreted sulfated glycoprotein and functions as a growth factor for primitive hematopoietic progenitor cells. An alternative splice variant has been described but its biological nature has not been determined. Sequence analysis revealed a 21aa signal peptide; a glutamate-rich N-terminal domain, which includes an arg-gly-asp triplet; a leucine zipper; and a C-terminal C-type lectin domain, which is known to be a carbohydrate recognition domain. The authors found O-glycan attachment sites but no N-glycosylation sites. Northern blot analysis detected a 1.4-kb transcript that was strongly expressed in T and B lymphoblastoid, weakly expressed in monocytoid cell lines, and not expressed in fibroblasts. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice