CHP (Calcium Binding Protein P22, SLC9A1BP, Calcineurin homologous protein, Calcineurin B-like protein, EF-hand calcium-binding domain-containing protein p22)

Size

£626.00

SKU:: 362559
Purity:: Purified by Protein A and peptide affinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Recombinant protein corresponding to Gly2-His195 of human CHP, expressed in E. coli.
Format:: Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Extra Details:: Calcium binding protein P22 is a phosphoprotein that binds to the sodium-potassium exchangers (NHEs). This protein serves as an essential cofactor which supports the physiological activity of NHE family members. It has protein sequence similarity to calcineurin B and it is also known to be an endogenous inhibitor of calcineurin activity. A partial sequence obtained from this screen was used to clone a novel full-length cDNA, designated CHP, from a second B-cell library. The deduced 195aa protein contains 2 distinct and 2 potential EF-hand Ca(2+)-binding motifs and shares 43% and 33% identity with calcineurin B and calmodulin, respectively. It also shares 99% sequence identity with the rat homolog. Northern blot analysis demonstrated expression of a 4-kb CHP transcript in all 8 fetal tissues examined. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice