362498
CDHP (Cadherin, Placental, CDH3, HJMD, PCAD, Cadherin 3 Type 1, P-Cadherin)
Size
£495.00
- SKU:
- 362498
- Purity:
- Purified by immunoaffinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to Ser565-Asp822 of mouse CDHP expressed in E. coli.
- Format:
- Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
- Extra Details:
- Placental cadherin (P-cadherin) is a member of the cadherin gene family. Other members include epithelial cadherin (E-cadherin) and neural cadherin (N-cadherin). A great deal is known about N- and E-cadherin. From the cancer standpoint, loss of E-cadherin in lobular breast cancer and in diffuse gastric cancer is a well-established tumor-initiating or promoting event. N-cadherin expression in mammary cell lines can stabilize fibroblast growth factor, resulting in an invasive phenotype. Until recently, P-cadherin was less studied with respect to cancer. It was originally identified as having an important role in implantation and embryogenesis in mice. In a development setting, Daniel et al. showed that P-cadherin is localized to the cap cells in the terminal end buds of the developing murine mammary gland. Applications: Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:100-5000 Western Blot: 1:50-400 Immunohistochemistry (frozen): 1:50-500 Immunohistochemistry (paraffin): 1:10-100 Immunocytochemistry: 1:50-500 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice