362370
CADM1 (BL2, IGSF4, IGSF4A, NECL2, RA175, ST17, SYNCAM, TSLC1, sTSLC-1, synCAM1, Tumor Suppressor In Lung Cancer 1, Immunoglobulin Superfamily, Member 4, Nectin-Like 2)
Size
£626.00
- SKU:
- 362370
- Application:
- WB
- Purity:
- Purified by Protein A and peptide affinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to Ala2-Phe22 of human CADM1 expressed in E. coli
- Format:
- Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
- Extra Details:
- Loss of genetic material at the cytogenetic level and loss of heterozygosity (LOH) are frequently observed in tumors. The 11q22-q24 region has deletions or LOH in a variety of tumor types. Replacement of the missing copy of chromosome 11 in the A549 adenocarcinoma cell line with a normal chromosome 11 reversed tumorigenicity in nude mice, suggesting the existence of a tumor suppressor gene. TSLC1 localized in perinuclear and plasma membranes. The predicted 442aa protein contains a signal peptide and a transmembrane domain. IGSF4 shares 65% identity with neural cell adhesion molecule-1 (NCAM1) and NCAM2 within their Ig-like C2-type domains. Northern blot analysis revealed expression of a 4.4kb transcript in all tissues tested except leukocytes. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice