362350
C4b (Complement Component 4b, CPAMD3, C4F, CO4, C4B1, C4B3, CH, C4(Chido Blood Group), Basic complement C4, C4a anaphylatoxin, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3)
Size
£524.00
- SKU:
- 362350
- Purity:
- Purified by immunoaffinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to Asn680-Arg756 of human C4b, expressed in E. coli
- Format:
- Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
- Extra Details:
- Complement component 4 is a protein involved in the complement system.It is cleaved into proteins 4a and 4b. C4b forms part of C3-convertase, in conjunction with 2a:C4b can bind CR1. C4b is the large fragment formed when Complement C4 is cleaved by Complement C1S. The membrane-bound C4b binds Complement C2A, a SERINE PROTEASE, to form C4b2a (CLASSICAL PATHWAY C3 CONVERTASE) and subsequent C4b2a3b (CLASSICAL PATHWAY C5 CONVERTASE). In 3 black-American patients with SLE, Wilson and Perez (1988) found complete deficiency of plasma C4B. In a 9-year-old girl with SLE and complete C4 deficiency, Welch et al. (1990) found uniparental isodisomy 6. The girl had 2 identical chromosome 6 haplotypes from the father and none from the mother. Applications: Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:100-5000 Western Blot: 1:50-400 Immunohistochemistry (frozen): 1:50-500 Immunohistochemistry (paraffin): 1:10-100 Immunocytochemistry: 1:50-500 Optimal dilutions to be determined by the researcher. AA Sequence: MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- N VNFQKAINEK LGQYASPTAK RCCQDGVTRL PMMRSCEQRA ARVQQPDCRE PFLSCCQFAE SLRKKSRDKG QAGLQR Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice