BMP3 (Bone Morphogenetic Protein 3, BMP3A, BMP-3A, Osteogenic)

Size

£505.00

SKU:: 362299
Purity:: Purified by Protein A and peptide affinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Recombinant protein corresponding to Lys313-Ser471 from bovine BMP3, fused with two N-terminal Tags, His-Tag and T7-tag expressed in E. coli.
Format:: Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Extra Details:: Bone morphogenetic protein 3 is a member of the transforming growth factor beta superfamily. It, like other bone morphogenetic proteins (BMP's) is known for its ability to induce bone and cartilage development. It is a disulfide-linked homodimer. It negatively regulates bone density. BMP3 is an antagonist to other BMP's in the differentiation of osteogenic progenitors. It is highly expressed in fractured tissues. Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification.Highly expressed in fracture tissue, particularly in osteoblasts, osteoclasts and chondroblasts. Expressed in adult and fetal cartilage. Applications: Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:100-1:5000 Western Blot: 1:50-400 Immunohistochemistry (frozen): 1:50-500 Immunohistochemistry (paraffin): 1:10-100 Immunocytochemistry: 1:50-500 Optimal dilutions to be determined by the researcher. AA Sequence: MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF-KEDEVWEE RKPYKTLQTQ PPDKSKNKKK QRKGPQQKSQ TLQFDEQTLK KARRKQWIEP RNCARRYLKV DFADIGWSEW IISPKSFDAY YCSGACQFPM PKSLKPSNHA TIQSIVRAVG VVPGIPEPCC VPEKMSSLSI LFFDENKNVV LKVYPNMTVE S Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice