BMP2 (Bone Morphogenetic Protein 2, BMP2A, BMP-2A, Hemochromatosis Modifier)

Size

£513.00

SKU:: 362295
Purity:: Purified by Protein A and peptide affinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Recombinant protein corresponding to Leu24-Arg395 from bovine BMP2, fused with two N-terminal Tags, His-Tag and T7-tag expressed in E. coli.
Format:: Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Extra Details:: Bone morphogenetic protein 2 or BMP-2 belongs to the TGF-Beta superfamily of proteins. BMP-2 like other bone morphogenetic proteins, plays an important role in the development of bone and cartilage. It is involved in the hedgehog pathway, TGF beta signaling pathway, and in cytokine-cytokine receptor interaction. It is involved also in cardiac cell differentiation and epithelial to mesenchymal transition. BMP-2 and BMP-7 are osteogenic BMPs: they have been demonstrated to potently induce osteoblast differentiation in a variety of cell types. Bone morphogenetic protein 2 is shown to stimulate the production of bone and recombinant human protein (rhBMP-2) and is currently available for orthopaedic usage in the United States. Applications: Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:100-1:5000 Western Blot: 1:50-400 Immunohistochemistry (frozen): 1:50-500 Immunohistochemistry (paraffin): 1:10-100 Immunocytochemistry: 1:50-500 Optimal dilutions to be determined by the researcher. AA Sequence: MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- LIPELGR RKFAASAGRS SSQPSDDVLS EFELRLLSMF GLKQRPTPSR DAVVPPYMLD LYRQHSGQPG APAPDHRLER AASLANTVRS FHHEESLEEL PEMSGKTTRR FFFNLTSIPT EEFITSAELQ VFRKHMPEAL ENNSSFHHRI NIYEIIKPAT ANSKFPVTRL LDTRLVTQNA SRWESFDVTP AVMRWTAQGL TNHGFVVEVA HPEDSHGASK RHVRISRSLH QDEHSWSQIR PLLVTFGHDG KGHPLHRREK RQAKHKQRKR LKSSCKRHPL YVDFSDVGWN DWIVAPPGYH AFYCHGECPF PLADHLNSTN HAIVQTLVNS VNSKIPKACC VPTELSAISM LYLDENEKVV LKNYQDMVVE GCGCR Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice