362235
ATXN1 (Ataxin 1, ATX1, SCA1, AXH Domain, Spinocerebellar Ataxia 1, Olivopontocerebellar Ataxia 1, Autosomal Dominant, Ataxin 1)
Size
£581.00
- SKU:
- 362235
- Application:
- WB
- Purity:
- Purified by Protein A and peptide affinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to Pro331-Asp587 of mouse ATXN1, expressed in E. coli.
- Format:
- Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
- Extra Details:
- The protein ataxin-1 is encoded by the ATXN1 gene, which is mutated to contain an expanded CAG trinucleotide repeat in spinocerebellar ataxia-1 (SCA1), an autosomal dominant form of olivopontocerebellar atrophy. Although there are forms of spinocerebellar ataxia that are indistinguishable clinically from SCA1, e.g., SCA2, the designation SCA1 is used for the form that maps to 6p. Banfi et al. (1994) demonstrated that the ATXN1 gene encodes an 816aa protein with a molecular mass of 87kD. The (CAG)n repeat, coding for a polyglutamine tract, lies within the coding region, and the protein is transcribed from both the wildtype and the CAG-expanded ATXN1 allele. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. AA Sequence: MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- PYESRHVVVH PSPADYSSRD TSGVRGSVMV LPNSSTPSAD LEAQQTTHRE ASPSTLNDKS GLHLGKPGHR SYALSPHTVI QTTHSASEPL PVGLPATAFY AGTQPPVIGY LSGQQQAITY AGGLPQHLVI PGNQPLLIPV GSPDMDTPGA ASAIVTSSPQ FAAVPHTFVT TALPKSENFN PEALVTQAAY PAMVQAQIHL PVVQSVASPT TASPTLPPYF MKGSIIQLAN GELKKVEDLK TEDFIQSAEI SNDLKID Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice