362066
AIM2 (Absent In Melanoma 2, PYHIN4, Interferon-inducible protein AIM2)
Size
£626.00
- SKU:
- 362066
- Application:
- WB
- Purity:
- Purified by Protein A and peptide affinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to Met1-Thr343 of human AIM2, expressed in E. coli.
- Format:
- Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
- Extra Details:
- AIM2 plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon- gamma induces expression of AIM2. AIM2 was expressed as a 39kD protein following in vitro transcription/translation in rabbit reticulocyte lysate or transfection in a murine epithelial cell line. Cell fractionation showed that AIM2 localized primarily to the cytoplasm of transfected mouse cells. Chromosome alterations in malignant melanoma most frequently include translocations and deletions on chromosome 1 or 6. AIM2 encodes a deduced 344aa protein that contains a conserved sequence domain of ~200aa shared with interferon-inducible genes as well as a tyrosine kinase phosphorylation site. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice