362007
ADCY1 (Adenylate Cyclase 1, Brain, AC1, ATP pyrophosphate-lyase 1, Ca(2+)/calmodulin- activated adenylyl cyclase, Adenylate cyclase type I)
Size
£524.00
- SKU:
- 362007
- Application:
- WB
- Purity:
- Purified by Protein A and peptide affinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to Arg835-Asn1061 of human ADCY1, expressed in E. coli.
- Format:
- Supplied as a liquid in 0.01M PBS, pH 7.4, 0.05% Proclin-300, 50% glycerol.
- Extra Details:
- Adenylate cyclase type 1 is aform of adenylate cyclase expressed in brain. A similar protein in mouse is involved in pattern formation of the brain. The neural-specific, calmodulin-sensitive adenylyl cyclase (type I), which was first cloned from bovine brain, has been implicated in learning and memory. Villacres et al. (1993) cloned the gene for human fetal brain type I adenylyl cyclase. By database analysis and PCR of human embryonic kidney cell cDNA, Ludwig and Seuwen (2002) cloned full-length ADCY1. The deduced protein contains 1,119aa. Semiquantitative RT-PCR detected ADCY1 highly expressed in peripheral blood leukocytes. Moderate or low ADCY1 levels were detected in brain and most other tissues examined except thymus, prostate, and small intestine. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. AA Sequence: MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- RILFNL LPAHVAQHFL MSNPRNMDLY YQSYSQVGVM FASIPNFNDF YIELDGNNMG VECLRLLNEI IADFDELMEK DFYKDIEKIK TIGSTYMAAV GLAPTSGTKA KKSISSHLST LADFAIEMFD VLDEINYQSY NDFVLRVGIN VGPVVAGVIG ARRPQYDIWG NTVNVASRMD STGVQGRIQV TEEVHRLLRR CPYHFVCRGK VSVKGKGEML TYFLEGRTDG N Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice