361936
A2BP1 (Ataxin 2 Binding Protein 1, RBFOX1, FOX1, HRNBP1, A2-BP1, Hexaribonucleotide Binding Protein 1, RNA Binding Protein, Fox-1 Homolog 1)
Size
£537.00
- SKU:
- 361936
- Application:
- WB
- Purity:
- Purified by Protein A and peptide affinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to Asp149-Ser399 of rat A2BP1, expressed in E. coli.
- Format:
- Supplied as a liquid in 0.01M PBS, pH 7.4, 0.05% Proclin-300, 50% glycerol.
- Extra Details:
- Ataxin-2 binding protein 1 has an RNP motif that is highly conserved among RNA-binding proteins. This protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the gene product of the SCA2 gene which causes familial neurodegenerative diseases. Ataxin-2 binding protein 1 and ataxin-2 are both localized in the trans-Golgi network. Four alternatively spliced transcript variants have been found for this gene. Additional transcript variants have been found but their full length nature has not been determined. Immunocytochemistry showed that A2BP1 was expressed in the cytoplasm of Purkinje cells and dentate neurons in a punctate pattern similar to that seen for ataxin-2 labeling. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. AA Sequence: MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- DP DLRQMFGQFG KILDVEIIFN ERGSKGFGFV TFENSADADR AREKLHGTVV EGRKIEVNNA TARVMTNKKA VNPYTNGWKL NPVVGAVYSP DFYAGTVLLC QANQEGSSMY SGPSSLVYTS AMPGFPYPAA TAAAAYRGAH LRGRGRTVYN TFRAAAPPPP IPAYGGVVYQ DGFYGADIYG GYAAYRYAQP TPATAAAYSD SYGRVYAADP YHHTLAPAPT YGVGAMNAFA PLTDAKTRSH ADDVGLVLS Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice