TNF alpha (Tumor Necrosis Factor Superfamily Member 2, TNFSF2, TNFA)

Size

£840.00

SKU:: 361672
Purity:: Purified by Protein A affinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Human
Immunogen:: Human TNF-alpha
Clone:: CDP 571 (Humicade) (recomb)
Format:: Supplied as a liquid in PBS, pH 7.2, 0.02% Proclin-300.
Extra Details:: Recombinant monoclonal antibody toTNF alpha with variable regions (i.e. specificity) from the hybridoma CDP 571 (Humicade). Manufactured using a proprietary recombinant platform technology. Not for therapeutic use; this is a research grade biosimilar. TNF-alpha is a pro-inflammatory cytokine which stimulates release of other cytiokines e.g. IL-1, IL-6 and GM-CSF as well as secretion of ICAM-1 and VCAM-1 from endothelial cells. It stimulates acute phase responses and acts as a chemoattractant for NK cells and monocytes/macrophages. The antibody reached Phase II clinical trials with Celltech, UCB. Applications: Suitable for use in ELISA and Neutralization. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.