361662
ITGA5 (VLA-5, Alpha 5 beta 1 Integrin, Fibronectin Receptor, CD49 Antigen-like Family Member E, Integrin alpha-F, CD49e) (Chimeric)
Size
£840.00
- SKU:
- 361662
- Purity:
- Purified by Protein A affinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Heterodimeric alpha5beta1Fc fusion protein.
- Clone:
- M200 (Volociximab) (recomb)
- Format:
- Supplied as a liquid in PBS, pH 7.2, 0.02% Proclin-300.
- Extra Details:
- Recombinant monoclonal antibody to ITGA5 with variable regions (i.e. specificity) from the hybridoma M200 (Volociximab). This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG4 format. Manufactured using a proprietary recombinant platform technology. Not for therapeutic use; this is a research grade biosimilar. The antibody binds specifically to alpha5beta1 integrin, which is part of the superfamily of glycoprotein transmembrane receptors for ligands such as fibronectin, vitronectin, laminins and collagens. The alpha5beta1 integrin receptor plays a key role in cellular processes such as inflammation, cell proliferation, angiogenesis and tumor metastasis. Comprising the variable domain of the original mouse antibody, a chimeric mouse:human IgG4 version of this antibody has been tested in vivo: In cynomolgus monkeys with laser-induced choroidal neovascularization (CNV), in rabbit models and in human volunteers. The antibody reached Phase II clinical trials with PDL Biopharma and Biogen-Idec. Applications: Suitable for use in Immunofluorescence, Flow Cytometry, ELISA, Immunohistochemistry and Blocking. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice