ErbB2 (Her-2/Neu, Metastatic Lymph Node Gene 19 Protein, MLN 19, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine Kinase-type Cell Surface Receptor HER2, p185erbB2, p185HER2) (Chimeric)

Size

£840.00

SKU:: 361585
Purity:: Purified by Protein A affinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: A431 cells (human epidermoid carcinoma) (over)expressing EGFR.
Clone:: 4D5-8 (trastuzumab) (recomb)
Format:: Supplied as a liquid in PBS, pH 7.2, 0.02% Proclin-300.
Extra Details:: Recombinant monoclonal antibody to ErbB2 with variable regions (i.e. specificity) from the therapeutic antibody 4D5-8 (trastuzumab). This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format. Manufactured using a proprietary recombinant platform technology. Not for therapeutic use; this is a research grade biosimilar. Oncogenic protein Her-2/neu (erbB-2), is a member of the family of epidermal growth factor (EGF) receptors, overexpressed in 30% of invasive breast cancers and 70% of ductal carcinomata in situ, in a small percentage of melanomas, and in other malignancies originating from various organs, including ovary, kidney, colon, and bladder. This antibody binds to erbB-2/Her-2/neu has therapeutic indications particularly in the treatment of breast cancer (c.f. Herceptin). Applications: Suitable for use in Flow Cytometry, ELISA and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice