EGFR (ERBB, ERBB1, HER1, PIG61, mENA, Avian Erythroblastic Leukemia Viral (v-erb-b) Oncogene Homolog, Cell Growth Inhibiting Protein 40, Cell Proliferation-inducing Protein 61, Proto-oncogene c-ErbB-1, Receptor Tyrosine-protein Kinase erbB-1, Epidermal Growth Factor) (Chimeric)

Size

£840.00

SKU:: 361581
Purity:: Purified by Protein A affinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Domain III of the extracellular domain of human EGRF.
Clone:: Matuzumab (recomb)
Format:: Supplied as a liquid in PBS, pH 7.2, 0.02% Proclin-300.
Extra Details:: Recombinant monoclonal antibody to EGFR with variable regions (i.e. specificity) from the therapeutic antibody Matuzumab. This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format. Manufactured using a proprietary recombinant platform technology. Not for therapeutic use; this is a research grade biosimilar. This antibody binds to human EGFR at a side distinct from the antigen binding site, preventing conformational re-arrangement required for dimerization, a process essential for high-affinitiy ligand binding (Schmiedel 2008). Applications: Suitable for use in Flow Cytometry, Western Blot and Blocking. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.