EGFR (ERBB, ERBB1, HER1, PIG61, mENA, Avian Erythroblastic Leukemia Viral (v-erb-b) Oncogene Homolog, Cell Growth Inhibiting Protein 40, Cell Proliferation-inducing Protein 61, Proto-oncogene c-ErbB-1, Receptor Tyrosine-protein Kinase erbB-1, Epidermal Growth Factor)

Size

£840.00

SKU:: 361576
Purity:: Purified by Protein A affinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Human
Immunogen:: Domain III of the extracellular domain of human EGRF.
Clone:: Matuzumab (recomb)
Format:: Supplied as a liquid in PBS, pH 7.2, 0.02% Proclin-300.
Extra Details:: Recombinant monoclonal antibody to EGFR with variable regions (i.e. specificity) from the therapeutic antibody Matuzumab. Manufactured using a proprietary recombinant platform technology. Not for therapeutic use; this is a research grade biosimilar. This antibody binds to human EGFR at a side distinct from the antigen binding site, preventing conformational re-arrangement required for dimerization, a process essential for high-affinitiy ligand binding (Schmiedel 2008). Applications: Suitable for use in Flow Cytometry, Western Blot and Blocking. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.