359956
CD20 (MS4A1, B-lymphocyte Antigen CD20, B-lymphocyte Surface Antigen B1, Bp35, Leukocyte Surface Antigen Leu-16, Membrane-spanning 4-Domains Subfamily A Member 1)
Size
£633.00
- SKU:
- 359956
- Application:
- WB
- Purity:
- Purified by immunoaffinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide corresponding to residues in human CD20.
- Format:
- Supplied as a liquid in PBS, pH 7.3, 0.05% sodium azide.
- Extra Details:
- CD20 is a leukocyte surface antigen consisting of four transmembrane regions and cytoplasmic N-terminal and C-terminal. The cytoplasmic domain of CD20 contains multiple phosphorylation sites, leading to additional isoforms. CD20 is expressed primarily on B cells but has also been detected on both normal and neoplastic T cells. CD20 functions as a calcium-permeable cation channel, and it is known to accelerate the G0 to G1 progression induced by IGF-1. CD20 is activated by the IGF-1 receptor via the alpha subunits of the heterotrimeric G proteins. Activation of CD20 significantly increases DNA synthesis and is thought to involve basic helix-loop-helix leucine zipper transcription factors. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilutions: Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice