TMEM107, NT (GRVS638, PRO1268, Transmembrane Protein 107)

Size

£655.00

SKU:: 352596
Purity:: Purified by immunoaffinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Peptide corresponding to 19aa from human TMEM107 at N-terminal.
Format:: Supplied as a liquid in PBS, 0.02% sodium azide.
Extra Details:: Transmembrane protein 107 (TMEM 107) is critical for cilia formation and embryonic patterning. It is a 139aa transmembrane protein encoded by a gene that maps to human chromosome 17 which is associated with two key tumor suppressor genes p53 and BRCA1. TMEM107 is required for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with Gli2 and Gli3 to pattern ventral and intermediate neuronal cell types. TMEM107 is also a strong candidate gene for central areolar choroidal dystrophy (CACD). Applications: Suitable for use in ELISA, Western Blot, Immunofluorescence, and Immunohistochemistry (paraffin). Other applications not tested. Recommended Dilution: Western Blot: 1-2ug/ml Optimal dilutions to be determined by the researcher. Positive Control: THP-1 Cell Lysate Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.