TFEB, CT (TCFEB, BHLHE35, ALPHATFEB, Transcription factor EB, Class E basic helix-loop-helix protein 35, bHLHe35)

Size

£655.00

SKU:: 352585
Purity:: Purified by immunoaffinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Peptide corresponding to 16aa near the C-terminal of human TFEB.
Format:: Supplied as a liquid in PBS, 0.02% sodium azide.
Extra Details:: The Transcription factor EB (TFEB) is a member in the basic helix-loop-helix leucine zipper superfamily of transcription factors that is translocated in a subset of renal tumors (1,2). Recent studies have shown that lysosomal biogenesis is regulated by TFEB (3), which is in turn regulated by the mammalian target of rapamycin (mTOR) complex 1 (4). Other evidence suggests that TFEB coordinates the major steps of the autophagic pathway by driving the expression of autophagy and lysosomal genes (5). Applications: Suitable for use in ELISA, Immunofluorescence, Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry: (paraffin) 2.5ug/ml. Optimal dilutions to be determined by the researcher. Positive Control: Lung Tissue Slide (Normal) Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.