IL-36B, CT (FIL1, FIL1H, IL1F8, IL1H2, IL-1F8, IL-1H2, IL1-ETA, Interleukin-36 beta, FIL1 eta, IL-1 eta)

Size

£655.00

SKU:: 352306
Purity:: Purified by immunoaffinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Peptide corresponding to 16aa near the C-terminal of human IL-36B.
Format:: Supplied as a liquid in PBS, 0.02% sodium azide.
Extra Details:: IL-36B is is a member of the interleukin 1 cytokine family whose gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2 (1). IL-36B is thought to activate the NF-kappaB pathway through IL-1 receptor family members IL-1RL2 and IL-1RAcP (2). Like the related proteins IL-36A and IL-36G, IL-36B requires post-translational processing for full agonist activity, but the cleavage mechanism is currently unknown (3). The IL-36 cytokines have been suggested to amplify Th1 responses by enhancing proliferation and Th1 polarization of naive CD4+ T cells (4). Applications: Suitable for use in Immunofluorescence, ELISA, Western Blot, Immunohistochemistry (paraffin). Other applications not tested. Recommended Dilution: Western Blot: 1-2ug/ml Optimal dilutions to be determined by the researcher Positive Control: A549 Cell Lysate Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.