352071

IgA, Fc (Immunoglobulin A, Fc)

Size

£716.00

SKU:: 352071
Purity:: Purified by Protein A affinity chromatography from cell culture
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Mouse
Immunogen:: IgA from human colostrum
Clone:: 16610
Format:: Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
Extra Details:: Human IgA (immunoglobulin A) is a glycosylated protein of 160kD and is produced as a monomer or as a J chain linked dimer. Monomeric IgA constitutes 5-15% of the serum immunoglobulins whereas dimeric IgA is localized to mucosa surfaces such as saliva, gastrointestinal secretion, bronchial fluids and milk. Mucosal IgA plays a major role in host defense by neutralizing infectious agents at mucosal surfaces. The production is usually local and antigen specific. IgA producing B cells can be found in regions under the lamina propria where they mature into dimeric IgA producing plasma cells. IgA deficiency is the most common immunodeficiency that may affect both serum and mucosal produced IgA. Applications: Suitable for use in detection of total IgA. Other applications not tested. Recommended Dilutions: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.