TICAM2, Recombinant, Human, aa1-235, His-Tag (TIR Domain-containing adapter molecule 2, TICAM-2, TIRAP3, TIRP, TRAM)

Size

£512.00

SKU:: 351519
Molecular Weight:: 29.4
Purity:: ~90% (SDS-PAGE)
Storage Conditions:: -20°C/-70°C
Supplier:: United States Biological
Format:: Supplied as a liquid in 20mM Tris-HCl, pH 8.0, 1mM DTT, 0.1M sodium chloride, 10% glycerol.
Extra Details:: Toll TIR domain-containing adapter molecule 2, also known as TICAM2, is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). TICAM-2, a cytoplasmic protein, physically bridges TLR4 and TICAM-1 and functionally transmits LPS-TLR4 signaling to TICAM-1, which in turn activates IRF-3. It is involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB. Source: Recombinant protein corresponding to aa1-235 from human TICAM2, fused to His-tag at N-terminal expressed in E. coli. Molecular Weight: ~29.4kD (259aa) AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSHMGIGKS KINSCPLSLS WGKRHSVDTS PGYHESDSKK SEDLSLCNVA EHSNTTEGPT GKQEGAQSVE EMFEEEAEEE VFLKFVILHA EDDTDEALRV QNLLQDDFGI KPGIIFAEMP CGRQHLQNLD DAVNGSAWTI LLLTENFLRD TWCNFQFYTS LMNSVNRQHK YNSVIPMRPL NNPLPRERTP FALQTINALE EESRGFPTQV ERIFQESVYK TQQTIWKETR NMVQRQFIA Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing.. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Shipping Conditions:: Blue Ice