Cxcl12, Recombinant, Mouse, aa22-89, His-Tag (Stromal cell-derived factor 1 Isoform alpha, Pbsf, Scyb12, Sdf1, Tlsf, Tpar1)

Size

£512.00

SKU:: 351170
Molecular Weight:: 10.4
Purity:: ~95% (SDS-PAGE)
Storage Conditions:: -20°C/-70°C
Supplier:: United States Biological
Format:: Supplied as a liquid in PBS, pH 7.4, 10% glycerol.
Extra Details:: Cxcl12 is also known as stromal cell-derived factor 1 isoform alpha. This protein acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. It stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. This protein inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Cxcl12 protein plays a protective role after myocardial infarction. It induces down-regulation and internalization of ACKR3 expressed in various cells. Source: Recombinant protein corresponding to aa22-89 from mouse Cxcl12, fused to His-tag at N-terminal expressed in E. coli. Molecular Weight: ~10.4kD (91aa) Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MGSKPVSLSY RCPCRFFESH IARANVKHLK ILNTPNCALQ IVARLKNNNR QVCIDPKLKW IQEYLEKALN K Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.