348101
Interleukin-11, active (IL11), Recombinant, Human
Size
£518.00
- SKU:
- 348101
- Molecular Weight:
- 19.1
- Purity:
- ≥95% as determined by SDS-PAGE and HPLC.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Format:
- Lyophilized from 0.2um filtered PBS, pH 7.4
- Extra Details:
- Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation (PubMed:12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. {ECO:0000250|UniProtKB:P47873, ECO:0000269|PubMed:12919066, ECO:0000269|PubMed:2145578}. Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine B9-11 cells is less than 1ng/ml, corresponding to a specific activity of ＞ 1.0x10e6 IU/mg. Sequence: MPGPPPGPPR VSPDPRAELD STVLLTRSLL ADTRQLAAQL RDKFPADGDH NLDSLPTLAM SAGALGALQL PGVLTRLRAD LLSYLRHVQW LRRAGGSSLK TLEPELGTLQ ARLDRLLRRL QLLMSRLALP QPPPDPPAPP LAPPSSAWGG IRAAHAILGG LHLTLDWAVR GLLLLKTRL Molecular Weight: 19.1kD PubMed ID: 2145578; 1828438; 1386338; 14702039; 15057824; 15489334; 12919066; 25195742 Gene Name: IL11 Swiss Prot: P20809 Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Shipping Conditions:
- Blue Ice