348043
Fibroblast Growth Factor 19, active (FGF19), Recombinant, Human
Size
£411.00
- SKU:
- 348043
- Molecular Weight:
- 21.8
- Purity:
- ≥95% as determined by SDS-PAGE and HPLC.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Format:
- Lyophilized from 0.2um filtered PBS, pH 7.4
- Extra Details:
- Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4. {ECO:0000269|PubMed:12815072, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:19085950}. Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine Balb/c 3T3 cells is less than 150ng/ml, corresponding to a specific activity of ＞6.7x10e3 IU/mg. Sequence: MRPLAFSDAG PHVHYGWGDP IRLRHLYTSG PHGLSSCFLR IRADGVVDCA RGQSAHSLLE IKAVALRTVA IKGVHSVRYL CMGADGKMQG LLQYSEEDCA FEEEIRPDGY NVYRSEKHRL PVSLSSAKQR QLYKNRGFLP LSHFLPMLPM VPEEPEDLRG HLESDMFSSP LETDSMDPFG LVTGLEAVRS PSFEK Molecular Weight: 21.8kD PubMed ID: 9931477; 10525310; 12975309; 15489334; 15340161; 12815072; 16597617; 17623664; 18829467; 19085950; 20094046; 14730967; 17339340 Gene Name: FGF19, UNQ334/PRO533 Swiss Prot: O95750 Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Shipping Conditions:
- Blue Ice