338169
TRIM28 (Tripartite Motif-Containing 28, Transcription Intermediary Factor 1-beta, RNF96, KAP1, TIF1B, Kap1, Tif1b, KRAB Associated Protein 1, KRAB Interacting Protein 1, KRAB-Associated Protein 1, KRAB-Interacting Protein 1, KRIP 1, KRIP1, KRIP-1, Krip1, Nuclear Corepressor KAP 1, Nuclear Corepressor KAP-1, RNF96, TIF1-beta)
Size
£800.00
- SKU:
- 338169
- Purity:
- Purified by immunoaffinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Human TRIM28
- Format:
- Supplied as a liquid in PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
- Extra Details:
- Tripartite motif-containing 28 (TRIM28), also known as transcriptional intermediary factor 1Beta (TIF1Beta) and KAP1 (KRAB-associated protein-1), is a protein that in humans is encoded by the TRIM28 gene. The protein encoded by this gene mediates transcriptional control by interaction with the Kruppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. KAP1 is a ubiquitously expressed protein involved in many critical functions including: transcriptional regulation, cellular differentiation and proliferation, DNA damage repair, viral suppression, and apoptosis. Its functionality is dependent upon post-translational modifications. Phosphorylation of KAP1 acts as a deactivator of the protein in many of its mechanisms while sumoylation acts as an activator. Applications: Suitable for use in Immunofluorescence, ELISA, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice