RASGEF1A

Size

£460.00

SKU:: 332101
Purity:: Purified by immunoaffinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Fusion protein of human RASGEF1A
Format:: Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide, 40% glycerol.
Extra Details:: RASGEF1A (RasGEF domain family, member 1A) is a 481aa guanine-nucleotide exchange factor (GEF) for H-Ras, K-Ras, and N-Ras. RASGEF1A may also play a role in cell migration. RASFEG1A is highly expressed in spinal chord and brain and contains one N-terminal Ras-GEF domain and one Ras-GEF domain. The gene that encodes RASGEF1A maps to human chromosome 10, which contains over 800 genes and 135 million nucleotides, making up nearly 4.5% of the human genome. PTEN is an important tumor suppressor gene located on chromosome 10 and, when defective, causes a genetic predisposition to cancer development known as Cowden syndrome. Applications: Suitable for use in ELISA and Immunohistochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:2000-1:5000 Immunohistochemistry: 1:20-1:100 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.