p18 INK (p18(INK4C), p18-INK4C, CDK6 Inhibitor p18, Cyclin-dependent Inhibitor)

Size

£544.00

SKU:: 327119
Purity:: Purified by immunoaffinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Synthetic peptide corresponding to human p18 INK.
Format:: Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 0.02% sodium azide, 50% glycerol.
Extra Details:: Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.Youzhong Yuan, Cancer Res., Jan 2006; 66: 343 - 351. A. Koenig, Vet. Pathol., Jul 2002; 39: 458. Pei-Fang Hung, Am J Physiol Cell Physiol, May 2005; 288: C1094 - C1108. Mana Mirjany, J. Pharmacol. Exp. Ther., May 2002; 301: 494. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:3000 Immunohistochemistry: 1:50-1:100 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.