CCR5 (phosphorylated Ser349)

Size

£518.00

SKU:: 309629
Application:: WB
Purity:: Purified by immunoaffinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Peptide corresponding to the sequence around phosphorylation site of Serine 349 (E-I-S(p)-V-G) derived from Human CCR5.
Format:: Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 0.02% sodium azide, 50% glycerol.
Extra Details:: Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.Martin Oppermann, J. Biol. Chem., Mar 1999; 274: 8875. Beatrix Pollok-Kopp, J. Biol. Chem., Jan 2003; 278: 2190 - 2198. Ramtin Rahbar, J. Virol., Jul 2006; 80: 7245 - 7259. H Olbrich, J. Leukoc. Biol., Mar 1999; 65: 281. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.