MERTK, NT (C MER, C Mer Proto Oncogene Tyrosine Kinase, C-mer, cMER, Cmer Protooncogene Tyrosine Kinase, Eyk, MER, MER Receptor Tyrosine Kinase, MERK, MERPEN, Mertk, MERTK C-mer Proto-oncogene Tyrosine Kinase, Nmf12, Nyk, Proto Oncogene Tyrosine Protein Kinase MER, Proto Oncogene Tyrosine Protein Kinase MER Precursor, Proto-oncogene c-Mer, Receptor Tyrosine Kinase MerTK, RP38, STK Kinase, Tyrosine-protein Kinase Mer)

Size

£620.00

SKU:: 303450
Application:: WB
Purity:: Purified by immunoaffinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Synthetic peptide corresponding to aa132-148, KDGKELLGAHHAITQFY, from human MERTK at N-terminus, different from the related mouse and rat sequences by 1aa.
Format:: Supplied as a lyophilized powder from PBS, 5% BSA, 0.05% thimerosal, 0.05% sodium azide. Reconstitute with 200ul sterile dH2O.
Extra Details:: Proto-oncogene tyrosine-protein kinase MER, also called MERTK is an enzyme that in humans is encoded by the MERTK gene. This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. This gene is mapped to 2q13. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. This gene is also very important in inhibition of Toll-like receptors(TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.1-0.5ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Shipping Conditions:: Blue Ice