ADRB2 (Alpha PAK, Alpha-PAK, P21 Activated Kinase 1, P21 Protein (Cdc42/Rac) Activated Kinase 1, P21-activated Kinase 1, P21/Cdc42/Rac1 Activated Kinase 1 (Yeast Ste20 Related), P21/Cdc42/Rac1-activated Kinase 1 (STE20 Homolog, Yeast), P65 PAK, P65-PAK, P68-PAK, PAK alpha, PAK-1, Pak1, Paka, PAKalpha, Protein Kinase MUK2, Rac/p21-activated Kinase, Serine/Threonine-protein Kinase PAK 1, STE20 Homolog Yeast)

Size

£620.00

SKU:: 303100
Application:: WB
Purity:: Purified by immunoaffinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Synthetic peptide corresponding to aa221-256, RVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGH, from the middle region of human ADRB2, different from the related mouse and rat sequences by 3aa.
Format:: Supplied as a lyophilized powder from PBS, 5% BSA, 0.05% sodium azide. Reconstitute with 200ul sterile dH2O.
Extra Details:: ADRB2, also known as beta-2 adrenergic receptor, is a beta-adrenergic receptor within a cell membrane which reacts with adrenaline (epinephrine) as a hormone or neurotransmitter affecting muscles or organs. It is mapped to 5q32. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. The genetic variation in the ADRB2 gene may be of major importance for obesity, energy expenditure, and lipolytic ADRB2 function in adipose tissue, at least in women. It has been found that activation of ADRB2 receptors can stimulate gamma-secretase activity and beta-amyloid production, and the ADRB2 receptors activator may contribute to beta-amyloid accumulation in AD. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.1-0.5ug/ml, the detection limit is ~0.1ng/lane under reducing conditions. Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Shipping Conditions:: Blue Ice