SPPL2B (Signal peptide Peptidase-like 2B, SPP-like 2B, SPPL2b, 3423-, Intramembrane Protease 4, IMP-4, Presenilin Homologous Protein 4, PSH4, Presenilin-like Protein 1, SPPL2B, IMP4, KIAA1532, PSL1)

Size

£698.00

SKU:: 302769
Application:: WB
Purity:: Purified by Protein A affinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: KLH conjugated synthetic peptide corresponding to aa126-160 from human SPPL2B.
Format:: Supplied as a liquid in PBS, 0.09% sodium azide.
Extra Details:: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF- alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. May play a role in the regulation of innate and adaptive immunity. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:2000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.