Orexin, Prepro, C-Terminal, Rat

Size

£336.00

SKU:: 302107
Molecular Weight:: 1628.87
Purity:: ~95% (HPLC)
Storage Conditions:: 4°C
Supplier:: United States Biological
Format:: Supplied as a white powder.
Extra Details:: Orexin-A and B were identified as endogenous ligands for the orexin-1 (HCRT1) and orexin-2 (HCRT2) G-protein coupled receptors (Sakurai et al, 1998). These peptides are identical to two hypothalamic peptides that share a high degree of homology with secretin, designated hypocretin-1 and hypocretin-2 (De Lecea et al, 1998). ICV administration of orexin-A and B stimulated food intake in rats. Additionally, prepro-orexin mRNA levels were upregulated in fasting rats. Recent reports suggest a role in the sleep-wake cycle. Molecular Weight: ~1628.87 Sequence: Cys-Pro-Thr-Ala-Thr-Ala-Thr-Ala-Leu-Ala-Pro-Arg-Gly-Gly-Ser-Arg-Val Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.