302038

MCT-CYC, aa68-85, Human (Cytochrome C)

Size

£451.00

SKU:: 302038
Molecular Weight:: 2048.54
Purity:: ~95% (HPLC)
Storage Conditions:: 4°C
Supplier:: United States Biological
Format:: Supplied as a white powder.
Extra Details:: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. Source: aa68-85, Human Molecular Weight: ~2048.54 Sequence: Leu-Glu-Asn-Pro-Lys-Lys-Tyr-Ile-Pro-Gly-Thr-Lys-Met-Ile-Phe-Val-Gly-Ile Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.