Munc13-4 (Not for Export EU)

Size

£544.00

SKU:: 301694
Purity:: Serum
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Format:: Supplied as a lyophilized powder. Reconstitute with 50ul sterile ddH2O.
Extra Details:: Protein unc-13 homolog D (Munc13-4) is involved in cytotoxic granule exocytosis in lymphocytes. It regulates assembly of recycling and late endosomal structures which leads to the formation of an endosomal exocytic compartment. It also regulates Ca2+-dependent secretory lysosome exocytosis in mast cells. Munc13- 4 is highly expressed in the spleen, thymus and leukocytes and to a lesser extent in the lung and placenta, brain, heart, skeletal muscle and kidney. Defects in Munc13-4 are the cause of hemophagocytic lymphohistiocytosis familial type 3 (FHL3). Applications: Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilutions: Western Blot: 1:2000 Immunoprecipitation: native Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.