Huntingtin-Interacting Protein 1 (HIP1)

Size

£550.00

SKU:: 301673
Purity:: Purified by immunoaffinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Peptide corresponding to human HIP1 at C-terminal.
Format:: Supplied as a lyophilized powder in PBS, pH 7.4, glycerol. Reconstitute with 100ul sterile ddH2O.
Extra Details:: Hungtinton’s disease (HD) is an inherited neurodegenerative disorder characterized by the expression of an expanded polyglutamine tract in the protein huntingtin. HIP1 (huntingtin interacting protein 1) binds to normal huntingtin but this interaction is lost in HD. HIP1 also binds to components of clathrin-coated pits and vesicles and is a marker of clathrin-coated membranes. HIP1 expression levels are altered in several types of cancer. Applications: Suitable for use in Immunofluorescence and Western Blot. Other applications not tested. Recommended Dilutions: Immunofluorescence: 1:10-1:100 Western Blot: 1:500-1:2500 Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.