301590
Calcineurin
Size
£576.00
- SKU:
- 301590
- Purity:
- Purified by Protein G affinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Mouse
- Immunogen:
- Full length bovine calcineurin
- Clone:
- VA1
- Format:
- Supplied as a lyophilized powder in PBS, pH 7.4. No preservative added. Reconstitute with 100ul sterile ddH2O.
- Extra Details:
- Within the last 30 years of research the biological roles of calcineurin have progressed from a putative inhibitor of the calmodulin dependent phosphodiesterase to the ground-breaking discovery that it is the target of immunosuppressant drugs such as cyclosporin A. As a serine/ threonine protein phosphatase, calcineurin participates in a number of cellular processes and Ca2+ dependent signal transduction pathways.Calcineurin plays a key role in regulating the transcription factor NF-AT during T-cell activation, and in mediating responses of microorganisms to cation stress. Recently, this protein was studied extensively in relation to diseases such as schizophrenia and diabetes. Applications: Suitable for use in ELISA, Western Blot, Immunoprecipitation, Immunohistochemistry and Immunocytochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:2000 Immunocytochemistry: 1:200 Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Shipping Conditions:
- Blue Ice