WISP1, Recombinant, Human (CCN4, WNT1-Inducible-Signaling Pathway Protein 1, CCN Family Member 4, Wnt-1-Induced Secreted Protein)

Size

£636.00

SKU:: 298315
Molecular Weight:: 67.3
Purity:: ≥90% (SDS-PAGE)
Storage Conditions:: -20°C
Supplier:: United States Biological
Format:: Supplied as a lyophilized powder in 0.1M glycine HCl, pH 3.0. No preservative added. Reconstitute with sterile ddH2O.
Extra Details:: Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan. Recombinant protein corresponding to human WISP1, fused to Fc-domain of human IgG, expressed in insect cell line. Molecular Weight: ~67.3kD Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.