297638
GM2-Oligosaccharide-sp (Biotin)
Size
£991.00
- SKU:
- 297638
- Molecular Weight:
- 1382.38
- Purity:
- Single Spot TLC
- Storage Conditions:
- 4°C
- Supplier:
- United States Biological
- Format:
- White powder
- Extra Details:
- GM2-oligosaccharide (sodium salt) is a trisaccharide (GalNAcβ1,4Galβ1,4Glc) with sialic acid linked α2,3 to the central galactose residue (Ledeen, 2009). The parent GM2 ganglioside is present on neuronal cells and plays a key role in the regulation of dendritogenesis in cortical pyramidal neurons. In lysosomal storage disorders, such as, Tay-Sachs and Sandhoff disease, where hexosaminases A and B are deficient, GM2 ganglioside accumulates in the nervous system (Cachon-Gonzalez, 2018). GM2 ganglioside is also overexpressed in melanomas and other tumors of neuro-ecto origin (Yoshida, 2020). Moreover, the sugar moiety of GM2 ganglioside is a receptor allowing viral infection of cells with reovirus and rotavirus (Zhu, 2018). Synonyms: GalNAcβ1,4Galβ1,4Glc Molecular Formula: C54H88N9O29S·Na Molecular Weight: 1,382.38 Appearance: White powder Purity (TLC): Single Spot Solubility: As reported Storage and Stability: Store at 4°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
- Shipping Conditions:
- Ambient