MPLA (PHAD, Monophosphoryl Lipid A, Phosphorylated Hexaacyl Disaccharide, Glycopyranoside Lipid A, Glucopyranosyl Lipid Adjuvant, GLA)

Size

£828.00

SKU:: 297346
Molecular Weight:: 1763.47
Purity:: ≥99%
Storage Conditions:: 4°C
Supplier:: United States Biological
CAS Number:: 1246298-63-4
Format:: Powder
Extra Details:: Toll-like receptor 4 (TLR4) activator. Activates TLR4 but does not activate TLR2 even at high concentrations. Defined structure of MPLA. Synthetic lipid A is structurally very similar to natural MPLA but does not exist in nature. Source: Synthetic. Does not contain RNA, DNA or protein fragments. CAS No: 1246298-63-4 Molecular Formula: C96H184N3O22P Molecular Weight: 1763.47 Appearance: Powder Purity: ≥99% Solubility: The solubility in ethanol (as well as other alcohols) and DMSO is limited. Additionally, this species is insoluble in water (aqueous buffers, serum etc.); however, it can be dispersed in an aqueous medium using a suitable emulsifier or detergent. This species is soluble in chloroform (at least up to 50mg/ml) and chloroform:methanol solvent systems, however gentle heating and sonication may be necessary to aid in dissolution. Dropwise additions of methanol or water may aid dissolution in chloroform at higher concentrations. If using in combination with other lipids, dissolve this lipid separately and then combine dissolved lipids in their respective solvent solutions. Storage and Stability: May be stored at 4°C. For long-term storage, aliquot and store at -20°C. Do not freeze. Aliquots are stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

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